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Symptoms of B12 deficiency include: a pale yellow tinge to your skin a sore and red tongue mouth ulcers changes in the way that you walk and move around disturbed vision irritability depression changes in the way you think, feel and behave When left untreated chronic B12 deficiency can lead to further health issues

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It was found that although the cell adhesion ability of PLGA scaffolds decreased after the addition of alkaline chitosan, cell migration and collagen secretion could still be promoted, while at the same time the scaffolds significantly reduced the recruitment of inflammatory cells and the formation of foreign body giant cells 235 (Figure 4d)