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Besides, there are some unresolved limitations in the use of HGs as scaffolds in tissue regeneration and vascularization, such as design challenges and dimensions of the gel network, the presence of inert modules that can destabilize microporous and macroporous structures, as well as the difficulty of producing rational scaffold designs that can efficiently mimic the morphology of the extracellular matrix (Xu et al., 2022)

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Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(−/−) and wild-type mice