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Subcutaneous injection produces plasma concentrations 2.5× higher than intranasal administration at equivalent doses, but nasal delivery bypasses hepatic first-pass metabolism entirely and reaches the CNS within 15 minutes
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Only then did the drug industry, and everyone else, change focus.” A final hurdle came in 2009, once the drug had gotten to phase three of testing for FDA approval: Thirteen patients in the 1,200-person trial were found to have elevated liver enzyme counts
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