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Supplements That Are Safe – but may not be very helpful specifically to isotretinoin therapy These supplements are commonly asked about but don’t help isotretinoin side effects: Collagen powders — fine, but won’t reduce dryness Protein powders — safe Magnesium — helps muscle cramps, not acne Vitamin C — safe, but no proven benefit Iron — only take if deficient Turmeric/curcumin — generally safe but may interact with blood thinners Other topical therapies to help with isotretinoin side effects These aren’t supplements but are extremely effective for managing dryness: Urea-based moisturisers (5–10%) Excellent for flaking or sensitivity

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If you adopt the dietary and lifestyle suggestions mentioned above and they don’t help, you might need medication

with the liver as its primary synthesis site