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Translating Kratom-Drug Interactions: From Bedside to Bench and Back - PMC

Keywords: obesity, therapeutics, nicotinamide N-methyltransferase, inhibitors, weight loss Graphical abstract 1

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In the phase III ORATORIO trial, 732 patients with primary progressive multiple sclerosis were randomly assigned in a 2:1 ratio to receive ocrelizumab 600 mg or placebo every 24 weeks for at least 120 weeks until the primary endpoint was met: 544 completed the double-blind period, of which 527 entered the open-label extension (75)