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(10-14) • A tripeptide, composed of glutamate, cysteine and glycine • Found in all cells, blood, bile and epithelial lining fluid of the lung • Synthesized by cells, particularly in the liver • The most abundant thiol-containing substance in cells • Has reduced and oxidized forms, GSH and GSSG • Ratio of GSH to GSSG controls the redox potential in cells • Serves as basis for the antioxidant system, quenching reactive oxygen species • Conjugates several classes of toxins for removal from the body in Phase II detox, and quenches free radicals generated in Phase I detox in general • Supports immune system, especially cell-mediated immunity • Plays important role in synthesis of proteins that contain cysteine • Participates in bile production • Has many other roles Methylation cycle and associated biochemical pathways (15-20) dietary protein Folate cycle Methylation cycle Transsulfuration pathway Sulfoxidation and synthesis of taurine and sulfate methionine methionine synthase homocysteine cysteine glutathione (GSH) What does the methylation cycle do

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The relevance of iron in the pathogenesis of Parkinson's disease