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Perhaps the best characterized of these transcription factors with dual regulation is the hypoxia-inducible factor 1 (HIF1) comprising the labile HIF1 α protein heterodimerized with the aryl hydrocarbon receptor nuclear translocator (ARNT or HIF1 β )
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In conclusion, the obtained results demonstrated that SH-SY5Y cells cultured in 3D were less sensitive to heavy metal toxicity compared to the 2D arrangement
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