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Considering that this amino acid is essential for central nervous system (CNS) function and development ( We found a significant decline in plasma sarcosine levels in LC patients, which is also reported in critically ill COVID-19 patients ( Despite previous reports on the role of tryptophan/serotonin in anxiety and depression ( The lower arginine in LC patients as reported in acute COVID-19 (58, 59) or the pathology associated with the effects of the virus on the endothelium (60)
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