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By inhibiting 3-hydroxy-3-methyl glutaryl-coenzyme A reductase, a rate-limiting enzyme in hepatocyte cholesterol synthesis catalyzing the creation of mevalonic acid, APS may lower CHOL synthesis ( By stimulating the sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor alpha (PPARα)/Fibroblast growth factor 21 (FGF21) pathway, APS could alleviate lipid metabolism disorder, notably, by increasing hepatic glycolipid metabolism, reducing inflammation, and lipid droplet deposition ( Furthermore, Li et al
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