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Based on the shallow voltage dependence of low-affinity II-V current suppression, the putative Zn 2+ -blocking site in Ca v 2.3 channels could reside in or at a superficial part of the pore near the outer vestibule rather than deep within the electric field, which is consistent with a number of previous studies on VGCC block by d-block metal ions (Winegar et al., 1991

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Never in mitosis gene A (NIMA)-related kinase 2 [ NEK2 ] increases the PKM2/PKM1 ratio by splicing PKM to promote enhanced glycolysis that drives oncogenesis ( Table 1 Pharmacologically targeting metabolic vulnerabilities in hematologic malignancies