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En los estudios con fibroblastos, los efectos aparecieron en concentraciones de 10 −12 a 10 −8 M y desaparecieron a concentraciones mayores, [4, 5] así que en cultivo celular conviene diseñar curvas amplias en lugar de una sola concentración alta

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These released exosomes can then modulate immune response in other cells through a payload of inflammatory cytokines, like TNF-alpha, or through microRNA s that decrease inflammation.[ref] Mast cell release of exosomes has been shown to increase the formation of collagen in fibroblasts, which can lead to fibrosis (including pulmonary fibrosis, IPF)