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Patients with diabetes have a 1.5- to 2.5-fold greater risk of pneumonia due to hyperglycemia and immune dysfunction [6]
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In the endoplasmic reticulum (ER), oxidative protein folding through the ER oxidoreductin 1 (ERO1)- protein disulfide isomerase (PDI) axis continuously generates H 2 O 2 , which is locally contained and recycled by peroxiredoxin 4 (PRDX4) and the glutathione (GSH)/thioredoxin (Trx) system (Fig
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