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Reported side effects with topical GHK-Cu generally include: Mild redness or warmth at the application site Temporary tingling sensation shortly after applying the product Occasional dryness or flaking as the skin adjusts Rare cases of temporary skin discoloration, sometimes called "copper uglies" in commercial discussions Allergic or irritant contact dermatitis in sensitive individuals Serious adverse events are not commonly reported in the topical literature currently available

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10.1038/ncomms12015 59 JaworskaJ.ZalewskaT.SypeckaJ.Ziemka-NaleczM