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Methylcobalamin, however, only occurs as a volatile intermediate product: reduced cobalamin (without a side group) accepts the methyl group of methylfolate (5-MTHF) and passes it on to homocysteine, producing methionine
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Hence, it is advised to strictly follow clinical practice guidelines and conduct a risk assessment for PN before administering potentially neurotoxic medications to MM patients (Richardson et al., 2012)
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