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It has been found that in the brains of AD patients, proteasome activity is reduced, and this change is negatively correlated with the number of NFTs, suggesting that inhibition of proteasome activity prevents the degradation of phosphorylated Tau proteins, which in turn promotes the formation of NFTs (Harris et al., 2020)
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In its reduced form, glutathione plays a key role in the regulation of reactive oxygen species (ROS) in the cell
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