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For central nervous system-directed therapy, a recommended dosage of Methotrexate Injection is 8000 mg/m 2 as an intravenous infusion over 4 hours as a single agent or in combination with immunochemotherapy at doses ranging from 3000 mg/m 2 to 8000 mg/m 2 followed by leucovorin rescue in accordance with high-dose methotrexate regimen guidelines [see Dosage and Administration ( 2.2)]