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Both prophylactic and therapeutic oral administration of Lacticaseibacillus rhamnosus Probio-M9 has shown remarkable efficacy in ICI therapy in controlling tumor growth, producing beneficial metabolites in the gut including butyric acid, alpha-ketoglutaric acid, n-acetyl-L-glutamate and pyridoxine

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These findings indicate that the antitumor effects of MnLR/Gly are mediated in part through gut microbiota modulation, in addition to its immunostimulatory and cytotoxic activities

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