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Coprine does not inhibit ALDH2 in vitro but does so in vivo as a consequence of its hydrolysis to its active metabolite, 1-amino cyclopropanol (Tottmar and Lindberg, 1977), which inhibits ALDH2 irreversibly through electrophilic attack and covalent modification of the Cys302 thiol (Marchner and Tottmar, 1983)
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