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In order to decrease the amount of tau phosphorylation and the formation of neurofibrillary tangles, siRNA against microtubule-associated protein tau (MAPT) has been shown to have a protective effect on synapse function and neuronal survival (101)
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The expression of occludin and zonula occludens-1 and SOD activity were increased, while the MDA amount was decreased by alpinetin in DSS-treated mice
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