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It was shown that the toxicity of OTA could be decreased by maintaining glutathione production with N -acetyl cysteine (NAC), which decreased reactive oxygen species (ROS) and 8-oxoguanine formation
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Furthermore, we recently demonstrated that oral administration of Immunocal in the G93A mutant SOD1 mouse model of ALS delayed disease onset and preserved grip strength to a significant degree, in comparison to untreated transgenic mice [70]
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