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National Library of Medicine: "B Vitamins" Mayo Clinic: "Biotin (Oral Route)" FDA: “FDA 101: Dietary Supplements” Mayo Clinic: "Anaphylaxis" Mayo Clinic: "Niacin" Mayo Clinic: "Allergies" Vitamin B12 - "Health Professional Fact Sheet" National Institutes of Health: "Vitamin B12 - Health Professional Fact Sheet" Journal of Allergy and Clinical Immunology: “Vitamin B12 Hypersensitivity: A Retrospective Multicenter Study” Justin Laube, MD Medical Reviewer Justin Laube, MD, is a dual board-certified integrative and internal medicine physician, retreat leader, and healing educator with over 15 years of experience caring for patients w

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A 2025 systematic review published in Orthopaedic Journal of Sports Medicine , covering 36 studies from 1993 to 2024, found that BPC-157 promotes healing by boosting growth factors and reducing inflammation, with improved outcomes across muscle, tendon, ligament, and bone injury models in animals.4 The peptide enhances growth hormone receptor expression in tendon fibroblasts — a key mechanism for tissue repair and regeneration.5 In the only published human orthopaedic data, seven of twelve patients with chronic knee pain reported relief lasting more than six months after a single BPC-157 injection.4 That is a small sample