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A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study
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It suppresses NF-kB signaling, a master switch for inflammation, and is discussed for systemic inflammatory load (Dalmasso et al., Am J Physiol Gastrointest Liver Physiol, 2008, PMID 18497334)
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