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The Phase 3 TRIUMPH-4 trial reported discontinuation rates of 12 to 18% due to adverse events in the retatrutide groups, compared to 4% in placebo (Lilly Press Release, Dec 2025)
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Why we landed on 0.10% โ and printed it Three principles drove the number: Stay in the evidence-supported, well-tolerated range for a copper signaling peptide, rather than chasing a high number for marketing
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