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Disease-Modifying Anti-Amyloid Therapies (Early AD) Lecanemab (Leqembi) — FDA-approved January 2023 (accelerated) and July 2023 (full approval) for early AD (MCI due to AD or mild AD dementia with confirmed amyloid pathology)
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Size and Gauge:31 Gauge, 0.5 mL, 5/16-inch
The presence of inflammatory molecules and reactive oxygen species triggers the upregulation of matrix metalloproteinases that disrupt tight junctions, degrade the BM, and damage cellular components of the NVU
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