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The UPR is mediated by three stress sensors—the inositol-requiring enzyme 1 (IRE1), the activating transcription factor 6 (ATF6) and protein kinase RNA-like ER kinase (PERK)—that activate a complex transcriptional cascade that leads to multiple adaptive responses or cell death (Hetz, 2012
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5.3 Hypoxia-activated prodrugs Hypoxia-activated prodrugs (HAPs) represent a rational strategy to exploit the hypoxic nature of tumors by selectively delivering cytotoxic agents to oxygen-deprived regions while sparing normoxic healthy tissue (271, 272)
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