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specifically, immunofluorescence analysis revealed that the expressions of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were significantly upregulated in the treated wounds, indicating effective promotion of angiogenesis and epithelialization [Figure 9D]
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Meanwhile, the possible explanation for predictions of the levels of the rest of the metabolites might be the existence of yet unknown regulatory mechanisms of the enzymes involved in producing or consuming these metabolites, which are not considered in the models
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