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The most common inclusion criterion for performing the surgical treatment is that 12 months must have elapsed from the onset of symptoms and evidence of stable curvature for at least 3 months 6

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In some embodiments, the PD-Ll binding antagonists include anti-PD-Ll antibodies, antigen binding fragments thereof, immunoadhesins, fusion proteins, oligopeptides and other molecules that decrease, block, inhibit, abrogate or interfere with signal transduction resulting from the interaction of PD-Ll with one or more of its binding partners, such as PD-1, B7-1