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Additionally, no significant benefits for glutathione are illustrated when neurotoxicity was assessed by physicians using the CTCAE scale for determining grade 2+ neurotoxicity (p=0.449) or the time to the development of grade 2+ neurotoxicity (p= 0.039, in favor of placebo arm) (Table 2 and Figure 4)

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Oxidative stress activates the intracellular signalling pathways that lead to the synthesis and release of these inflammatory mediators, the proinflammatory transcription factor nuclear factor-κB (NF-κB) and signalling molecules such as Ras/Rac, p38 mitogen-activated protein kinase (MAPK), Jun- N -terminal kinase (JNK), PI3 kinase, and protein tyrosine phosphatases