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mtROS acts not only as a destructive oxidant but also as a significant signaling molecule, regulating IL-1β release and pyroptosis, thereby further amplifying the inflammatory cascade and impacting neighboring cardiomyocytes ( 2.3.4 Induction of ferroptosis Emerging evidence suggests a link between macrophage metabolic reprogramming and the induction of ferroptosis, presenting a potential novel axis in the pathogenesis of SRMI ( 2.3.5 Amplification of oxidative and nitrosative stress In SRMI, oxidative and nitrosative stress arise from a concerted overproduction of ROS/RNS across multiple cardiac cell types

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SKU: 94524342275
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