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5 pM each, 10 pM each, 15 pM each, or higher) and are allowed to form immune complexes at a neutral pH, and wherein the binding stoichiometry is measured by analytical size exclusion chromatography (SEC) and (e) is capable of binding to the antigen with a 1 :1 antibody-to-antigen stoichiometry, when the antibody: antigen complex is present at lower concentrations (e.g., at 0.45 pM or lower)
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