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1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords “Parkinson’s disease,” “ α -synuclein,” “dopaminergic neurons,” “LRRK2,” “mitochondrial dysfunction,” “comorbidities,” “levodopa,” and “neuroinflammation.” Studies published in English between 2000 and 2025 were included