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Hormonal Recovery and System Reset While traditional SERM-based PCT (e.g., Clomid, Nolvadex) may not be necessary after HGH or IGF-1 LR3 alone, users should still support: Liver and metabolic health Insulin sensitivity restoration Endogenous IGF-1 balance Testosterone production (if steroids were included) “Prolonged use of IGF-1 analogs may lead to negative feedback on GH/IGF axis and necessitate time off or tapering for hormonal normalization.” — Baxter, R