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In a rat model of chemically induced colon cancer, inhibition of cell proliferation by aged garlic extract was associated with a reduction in the incidence of precancerous lesions and dysplastic adenomas, but not of adenocarcinomas (72)
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Chromatin status is driven by the activity and level of chromatin-modifying enzymes such as DNA methyltransferases (DNMT) and histone deacetylases (HDAC) (90) ( Figure 2 )
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