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While the TC scaffold serves as a strong foundation for designing DNA-damaging candidates, advancing TC-Py to the clinic will require investigation into its in vivo biological stability when complexed with bioavailable copper

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A multi-functional chemical conjugation molecule, comprising a localizing moiety, a chemical linker moiety, an activator moiety, a first orienting adaptor interconnecting the chemical linker moiety on one end to the activator moiety, and optionally a second orienting adaptor interconnecting the chemical linker molecule on a different end to the localizing moiety